Disintegrant: GOOD VS BAD

Pharmaceutical capsules and tablets contain inactive ingredients called disintegrants. The main purpose of a disintegrant is timing the release of active ingredients, helping with absorption or bioavailability. These mechanisms can lead to mild digestive discomforts.


There are several disintegrants approved by the FDA  and are common in supplements. To learn more about disintegrants, we will evaluate each one.


By James Herb  Updated : 3/8/2024

Croscarmellose Sodium Pros and Cons


This disintegrant is crucial for supplements that require quick release. Croscarmellose sodium is derived from cellulose, a natural polymer and component of the cell walls of plants. Croscarmellose sodium can absorb water rapidly. This causes the capsule to swell and break down quickly, releasing the active ingredients into the body.



Croscarmellose sodium is a food additive that should be approached with caution when integrated into your meals. Croscarmellose sodium is not absorbed by the gastrointestinal tract and some individuals can experience digestive discomforts such as bloating, gas, diarrhea, and cramps. There have also been reports of allergic reactions, which can be subtle or delayed and include:

Allergic Reactions:

  • Rashes or hives
  • Difficulty breathing
  • Dizziness and rapid heart rate
  • Swelling of face, lips, and throat